Epidemiological and clinicopathological characteristics of mammary tumors in female dogs: A retrospective analysis
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https://orcid.org/0000-0003-2689-6477
Abstract
Mammary tumors are common neoplasms in female dogs and pose a clinical challenge because of their high malignancy potential. This retrospective study analyzed the medical records of 724 female dogs with 1,638 mammary tumors treated between 2012 and 2022 to assess epidemiological and clinicopathological associations. Malignant tumors (84.6%) were larger than benign ones (3.4 cm vs. 2.3 cm, P<0.01) and were associated with advanced age, multiple tumors, size >5 cm, and ulceration. Tumors >5 cm in size were associated with histological grade III, ulceration, adhesion, and regional metastases. In the multivariate analysis, tumor malignancy was 3.2 times more likely with each additional tumor, 3.3 times more likely with each additional year of age, and 4.8 times more likely with ulcerated tumors. These findings highlight the importance of early diagnosis, comprehensive evaluation, and regular monitoring, especially in high-risk dogs such as elderly and overweight female dogs.
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References
Ariyarathna, H., Aberdein, D., Thomson, N., Gibson, I., & Munday, J. S. (2022). Canine mammary gland disease in New Zealand: A review of samples from 797 dogs. New Zealand Veterinary Journal, 70(2), 95-100. https://doi.org/10.1080/00480169.2021.2004953
Banchi, P., Morello, E. M., Bertero, A., Ricci, A., & Rota, A. A. (2021). Retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy. Veterinary and Comparative Oncology, 20(1), 172-178. https://doi.org/10.1111/vco.12759
Burrai, G. P., Gabrieli, A., Moccia, V., Zappulli, V., Porcellato, I., Brachelente, C., Pirino, S., Polinas, M., & Antuofermo, E. (2020). A statistical analysis of risk factors and biological behavior in canine mammary tumors: A multicenter study. Animals (Basel), 10(1687), 1-12. https://doi.org/10.3390/ani10091687
Carvalho, P. T., Niza-Ribeiro, J., Amorim, I., Queiroga, F., Severo, M., Ribeiro, A. I., & Pinello, K. (2023). Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal. Frontiers in veterinary science, 10, 1271097. https://doi.org/10.3389/fvets.2023.1271097
Cassali, G. D., Jark, P. C., Gamba, C., Damasceno, K. A., Lima, A. E., Nardi, A. B., Ferreira, E., Horta, R. S., Firmo, B. F., Sueiro, F. A. R., Rodrigues, L. C. S., & Nakagaki, K. Y. R. (2020). Consensus regarding the diagnosis, prognosis, and treatment of canine and feline mammary tumors – Belo Horizonte. Brazilian Journal of Veterinary Pathology, 13(3), 555–574. https://doi.org/10.24070/bjvp.1983-0246.v13i3p555-574
Daleck, C. R., Franceschini, P. H., Alessi, A. C., Santana, A. E., & Martins, I. Z. M. M. (1998). Aspectos clínico e cirúrgico do tumor mamário canino. Ciência Rural, 28(1), 731–735. https://doi.org/10.1590/S0103-84781998000100016
Dias, M. L. D. M., Andrade, J. M. L., Castro, M. B. D., & Galera, P. D. (2016). Survival analysis of female dogs with mammary tumors after mastectomy: Epidemiological, clinical, and morphological aspects. Pesquisa Veterinária Brasileira, 36(3), 181-186. https://doi.org/10.1590/S0100-736X2016000300006
Dolka, I., Czopowicz, M., Stopka, D., Wojtkowska, A., Kaszak, I., & Sapierzyński, R. (2024). Risk factor analysis and clinicopathological characteristics of female dogs with mammary tumours from a single-center retrospective study in Poland. Scientific Reports, 14, 5569. https://doi.org/10.1038/s41598-024-56194-z
Elston, C. W., & Ellis, I. O. (1991). Pathological prognostic factors in breast cancer: The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology, 19(1), 403–410. https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
Ferreira, E., Bertagnolli, A. C., Cavalcanti, M. F., Schmitt, F. C., & Cassali, G. D. (2009). The relationship between tumor size and expression of prognostic markers in benign and malignant canine mammary tumors. Veterinary and Comparative Oncology, 7(4), 230–235. https://doi.org/10.1111/j.1476-5829.2009.00193.x
Gedon, J., Wehrend, A., Failing, K., & Kessler, M. (2020). Canine mammary tumours: Size matters—a progression from low to highly malignant subtypes. Veterinary and Comparative Oncology, 19(4), 707-713. https://doi.org/10.1111/vco.12649
Goldschmidt, M., Peña, L., Rasotto, R., & Zappulli, V. (2011). Classification and grading of canine mammary tumors. Veterinary Pathology, 48(1), 117-131. https://doi.org/10.1177/0300985810393258
Goldston, R. T., & Hoskins, J. D. (1999). Geriatria e gerontologia em cães e gatos (p. 551). Roca.
Jing Z, Feng J, Jin H. (2024). Epidemiological investigation and surgical treatment of canine mammary tumors in Dalian, China, from 2019 to 2023. PLoS One, 19(11), e0314292. https://doi.org/10.1371/journal.pone.0314292
Laflamme, D. P. (1997). Development and validation of a body condition score system for dogs: A clinical tool. Canine Practice, 22(3), 10-15.
Lim, H. Y., Im, K. S., Kim, N. H., Kim, H. W., Shin, J. I., Yhee, J. Y., & Sur, J. H. (2015). Effects of obesity and obesity-related molecules on canine mammary gland tumors. Veterinary Pathology, 52(6), 1045-1051. https://doi.org/10.1177/0300985815579994
Marconato, L., Romanelli, G., Stefanello, D., Giacoboni, C., Bonfanti, U., Bettini, G., Finotello, R., Verganti, S., Valenti, P., Ciaramella, L., & Zini, E. (2009). Prognostic factors for dogs with mammary inflammatory carcinoma: 43 cases (2003-2008). Journal of the American Veterinary Medical Association, 235(8), 967–972. https://doi.org/10.2460/javma.235.8.967
Nunes, F. C., Campos, C. B., Teixeira, S. V., Bertagnolli, A. C., Lavalle, G. E., & Cassali, G. D. (2018). Epidemiological, clinical, and pathological evaluation of overall survival in canines with mammary neoplasms. Arquivos Brasileiros de Medicina Veterinária e Zootecnia, 70(6), 1714-1722. https://doi.org/10.1590/1678-4162-10217
Oliveira, L. C., Fernandes, M. E. D. S. L., Peixoto, A. J. R., Barros, F. F. P. D. C., Coelho, C. M. M., Nogueira, V. A., & Caldas, S. A. (2022). Clinical, epidemiological, and histopathological aspects of breast cancer in female dogs at Federal Rural University of Rio de Janeiro Veterinary Hospital. Brazilian Journal of Veterinary Medicine, 44, e000722. https://doi.org/10.29374/2527-2179.bjvm000722
Prates, K. S., Oliveira, P. L., Bueno, T. S., Damasceno, K. A., Driemeier, D., Sonne, L., & Bertagnolli, A. C. (2023). A comparative analysis of anatomopathological features and COX-2 expression of mammary neoplasms with malignant mesenchymal components in female dogs. Pesquisa Veterinária Brasileira, 43(07186), 1–7. https://doi.org/10.1590/1678-5150-PVB-7186
Pecile, A. D., Groppetti, R., Ferrari, V., Grieco, C., Giudice, C., Spediaccia, D., Stefanello, P., & Borachi, A. (2021). Solitary and multiple simultaneous malignant epithelial mammary tumours in dogs: an explorative retrospective study. Research in Veterinary Science, 135, 153–161. https://doi.org/10.1016/j.rvsc.2021.01.014
Rao, N. A., van Wolferen, M. E., Gracanin, A., Bhatti, S. F., Krol, M., Holstege, F. C., & Mol, J. A. (2009). Gene expression profiles of progestin-induced canine mammary hyperplasia and spontaneous mammary tumors. Journal of Physiology and Pharmacology, 60(1), 73-84.
Rasotto, R., Berlato, D., Goldschmidt, M. H., & Zappulli, V. (2017). Prognostic significance of canine mammary tumor histologic subtypes: An observational cohort study of 229 cases. Veterinary Pathology, 54(4), 571-578. https://doi.org/10.1177/0300985817698208
Rodríguez, J., Santana, Á., Herráez, P., Killick, D. R., & de Los Monteros, A. E. (2022). Epidemiology of canine mammary tumours on the Canary Archipelago in Spain. BMC Veterinary Research, 18(268), 1-14. https://doi.org/10.1186/s12917-022-03363-9
Salas, Y., Márquez, A., Diaz, D., & Romero, L. (2015). Epidemiological study of mammary tumors in female dogs diagnosed during the period 2002-2012: A growing animal health problem. PLOS ONE, 10(5), 1-15. https://doi.org/10.1371/journal.pone.0127381
Santos, T. R., Castro, J. R., Andrade, J. C., Silva, A. C. R., Silva, G. M. F., Ferreira, F. A., & Headley, S. A. (2020). Risk factors associated with mammary tumors in female dogs. Pesquisa Veterinária Brasileira, 40(6), 466-473. https://doi.org/10.1590/1678-5150-PVB-6360
Schafer, K. A., Kelly, G., Schrader, R., Griffith, W. C., Muggenburg, B. A., Tierney, L. A., Lechner, J. F., Janovitz, E. B., & Hahn, F. F. (1998). A canine model of familial mammary gland neoplasia. Veterinary Pathology, 35(3), 168–177. https://doi.org/10.1177/030098589803500302
Silva, E. M. G. D., Santos, T. R. D., & Silva, M. J. B. (2023). Identifying the risk factors for malignant mammary tumors in dogs: A retrospective study. Veterinary Sciences, 10(10), 607. https://doi.org/10.3390/vetsci10100607
Soares, E. D. S., Valente, F. L., Rocha, C. C., Real Pereira, C. E., Sarandy, T. B., de Oliveira, F. L. D., de Morais Calado, S. L., & Borges, A. P. B. (2023). Prognostic factors for cancer-specific survival and disease-free interval of dogs with mammary carcinomas. Veterinary Medicine International, 2023(6890707), 1-12. https://doi.org/10.1155/2023/6890707
Sorenmo, K. U., Kristiansen, V. M., Cofone, M. A., Shofer, F. S., Breen, A. M., Langeland, M., Mongil, C. M., Grondahl, A. M., Teige, J., & Goldschmidt, M. H. (2009). Canine mammary gland tumours: a histological continuum from benign to malignant; clinical and histopathological evidence. Veterinary and Comparative Oncology, 7(3), 162–172. https://doi.org/10.1111/j.1476-5829.2009.00184.x
Tesi, M., Millanta, F., Poli, A., Mazzetti, G., Pasquini, A., Panzani, D., Rota, A., & Vannozzi, I. (2020). Role of body condition score and adiponectin expression in the progression of canine mammary carcinomas. Veterinary Medicine and Science, 6(3), 265–271. https://doi.org/10.1002/vms3.238
Tolosa, E. M. C. de, Rodrigues, C. J., Behmer, O. A., & Freitas Neto, A. G. de. (2003). Manual de técnicas para histologia: Normal e patológica. São Paulo: Manole
Vascellari, M., Capello, K., Carminato, A., Zanardello, C., Baioni, E., & Mutinelli, F. (2016). Incidence of mammary tumors in the canine population living in the Veneto region (Northeastern Italy): Risk factors and similarities to human breast cancer. Preventive Veterinary Medicine, 126, 183-189. https://doi.org/10.1016/j.prevetmed.2016.02.008
Vazquez, E., Lipovka, Y., Cervantes-Arias, A., Garibay-Escobar, A., Haby, M. M., Queiroga, F. L., & Velazquez, C. (2023). Canine Mammary Cancer: State of the Art and Future Perspectives. Animals, 13(19), 3147. https://doi.org/10.3390/ani13193147
Withrow, S. J., Vail, D. M., & Page, R. L. (2013). Withrow & MacEwen’s small animal oncology (5th ed., 768 p.). Elsevier.
Zheng, H. H., Du, C. T., Yu, C., Zhang, Y. Z., Huang, R. L., Tang, X. Y., & Xie, G. H. (2022). Epidemiological investigation of canine mammary tumors in mainland China between 2017 and 2021. Frontiers in Veterinary Science, 9(843390), 1-10. https://doi.org/10.3389/fvets.2022.843390