Copper toxicosis with hepatic cirrhosis in three dogs: report of a safety alert

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Austral Journal of Veterinary Sciences
pdf (English)
Publicado: Dec 10, 2025
DOI: https://doi.org/10.4206/ajvs.57.18

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Carlos A. Flores Olivares
Laboratorio de Investigación de Ciencias Veterinarias, Facultad de Ciencias Agropecuarias, Universidad del Alba, La Serena, Chile.
https://orcid.org/0000-0002-7837-3849
Ignacio Oroquieta-Fairlie
Facultad de Ciencias, Universidad Mayor, Santiago, Chile.
https://orcid.org/0000-0001-8748-0411
Constanza Cubillos-Torres
Independent researcher.
Alejandra A. Covarrubias
Laboratorio de Investigación de Ciencias Veterinarias, Facultad de Ciencias Agropecuarias, Universidad del Alba, La Serena, Chile.
Diana Leiva-Portilla
Laboratorio de Investigación de Ciencias Veterinarias, Facultad de Ciencias Agropecuarias, Universidad del Alba, La Serena, Chile.
https://orcid.org/0000-0002-0042-8870

Resumen

In 2020, hundreds of thousands of dogs in Chile were exposed to toxic copper levels in commercial dog food, exceeding the legal copper limit tenfold. We report three fatal hepatic cirrhosis cases after at least three months of consumption of this product. All showed advanced stage liver injury, micro and macroscopic lesions, and high hepatic copper levels.

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Cómo citar
Flores Olivares, C. A., Oroquieta-Fairlie, I., Cubillos-Torres, C., Covarrubias, A. A., & Leiva-Portilla, D. (2025). Copper toxicosis with hepatic cirrhosis in three dogs: report of a safety alert. Austral Journal of Veterinary Sciences, 57, e570118. https://doi.org/10.4206/ajvs.57.18
Número
Vol. 57 (2025)
Sección
CASE REPORT
Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Referencias

Amundson, L.A, Kirn, B.N, Swensson, E.J, Millican, A.A., & Fahey, G.C. (2024). Copper metabolism and its implications for canine nutrition. Translational Animal Science, 8, txad147. https://doi.org/10.1093/tas/txad147

Center, S.A. (2025). Uncovered Truths About Liver Copper Accumulation in Dogs: Additional 2023-24 Studies. In: ACVIM Forum 2025, Louisville, Kentucky, June 19, 2025. [Unpublished abstract].

Center, S., Richter, K., Twedt, D., Wakshlag, J., Watson, P., & Webster, C. (2021). Is it time to reconsider current guidelines for copper content in commercial dog foods? Journal of the American Veterinary Medical Association, 258(4), 357-364. https://doi.org/10.2460/javma.258.4.357

Chen, L., Min, J., & Wang, F. (2022) Copper homeostasis and cuproptosis in health and disease. Signal Transduction and Targeted Therapy, 7, 378. https://doi.org/10.1038/s41392-022-01229-y

Chen, J., Jiang, Y., Shi, H., Peng, Y., Fan, X., & Li, C. (2020). The molecular mechanisms of copper metabolism and its roles in human diseases. Pflügers Archive, 472, 1415-1429. https://doi.org/10.1007/s00424-020-02412-2

FEDIAF (2024). Nutritional Guidelines for Complete and Complementary Pet Food for Cats and Dogs. Retrieved from https://europeanpetfood.org/wp-content/uploads/2024/09/FEDIAF-Nutritional-Guidelines_2024.pdf

Fieten, H., Biourge, V., Watson, A., Laegwater, P., Van den Ingh, T., & Rothuizen, J. (2014). Nutritional management of inherited copper-associated hepatitis in the Labrador retriever. The Veterinary Journal, 199(3), 429-433. https://doi.org/10.1016/j.tvjl.2013.12.017

Hoffman, W.E. (2009). Copper-Associated Liver Disorders. Veterinary Clinics of North America: Small Animal Practice, 39(3), 489–511. https://doi.org/10.1016/j.cvsm.2009.02.001

Johnston, A.N., Center, S.A., McDonough, S.P., Wakshlag, J.J., & Warner, K.L. (2013). Hepatic copper concentrations in Labrador Retrievers with and without chronic hepatitis: 72 cases (1980–2010). Journal of the American Veterinary Medical Association, 242(3), 372–380. https://doi.org/10.2460/javma.242.3.372

Langlois, D.K., Smedley, R.C., Schall, W.D., & Kruger, J.M. (2013). Acquired proximal renal tubular dysfunction in 9 Labrador Retrievers with copper-associated hepatitis (2006–2012). Journal of Veterinary Internal Medicine, 27(3), 491–499. https://doi.org/10.1111/jvim.12065

Nivy, R., Kuzi, S., Swinburne, J., Constantine-Casas, F., Gajanayake, I., Bruchim, Y., Berkowitz, A., Watson, P. (2024). Copper-associated chronic hepatitis in Cavalier King Charles spaniels. Veterinary Record, 194(3), e3561. https://doi.org/10.1002/vetr.3561

Paßlack, N., Mainzer, B., Lahrssen-Wiederholt, M., Schafft, H., Palavinskas, R., Breithaupt, A., Neumann, K., & Zentek, J. (2015). Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in the equine liver and kidneys. Journal of veterinary Science, 16(1), 57-66. https://doi.org/10.4142/jvs.2015.16.1.57

Servicio Nacional del Consumidor (SERNAC) (2020). Alerta de seguridad: Alimento para perros Cannes y Charly, años 2019-2020. https://www.sernac.cl/portal/619/w3-article-58617.html

Servicio Agrícola y Ganadero (SAG). SAG establece que alimentos para perros Cannes no son aptos para consumo animal; Alertas Informativas SAG [Internet]. 2020 Jul 10 [cited 2025 September 26]. Available from: https://www.sag.gob.cl/content/alertas-informativas-sag-470

Strickland, J.M., Buchweitz, J.P., Smedley, R.C., Olstad, K.J., Schulz, R.S., Oliver, N.B., & Langlois, D.K. (2018). Hepatic copper concentrations in 546 dogs (1982–2015). Journal of Veterinary Internal Medicine, 32(6), 1943–1950. https://doi.org/10.1111/jvim.15308

Thornburg, L.P. (2000) A perspective on copper and liver disease in the dog. Journal of Veterinary Diagnostic and Investigation, 12(2), 101–110. https://doi.org/10.1177/104063870001200201